The results of the research indicate that some people with chronic pain practice self – medication with cannabis . However, there are too few human studies to determine whether cannabis or cannabinoids actually relieve chronic pain. But most of this research is based on subjective statements, on personal assessments of pain, which limits its validity. Only a few controlled clinical trials have been conducted to date, which makes it unclear whether cannabis is an effective pain treatment.
Another approach is to look at the combination of several drugs, namely an experimental drug based on cannabinoids associated with a drug already known. For example, a recent mouse study combined a low dose of THC-based medication with an aspirin drug. However, this combination blocks the pain associated with nerve endings better than each of these drugs does individually.
Theoretically, such combinations make it possible to use lesser amounts of each substance, and the side effects are thus reduced. In addition, some people may be more receptive to one substance than the other, which optimizes the chances that the combination will be suitable for more patients. But for the moment, no such study has been conducted on humans.
The effects of cannabis on epilepsy:
Despite some sensational articles and even though speculation is rife on the Internet, the therapeutic use of cannabis to reduce epileptic seizures is currently confirmed only by experiments on rodents .
In humans, evidence of its effectiveness is much less established. There are many anecdotes and surveys that extol the virtues of cannabis flowers or cannabis extracts to treat epilepsy. But these statements cannot be compared to properly controlled clinical trials to determine whether certain types of epileptic seizures respond positively to the effects of cannabinoids and to provide stronger evidence of how most people respond to this substance
Although CBD attracts attention as a potential treatment for epileptic seizures in humans, nothing is known about the physiological link between the substance and its effects. As with chronic pain, the few clinical studies that have been conducted include very few patients . By studying larger groups, we may discover if only some patients are receptive to CBD.
We also need to know more about cannabinoid receptors in the brain and the body, to understand what systems they regulate, and how CBD can influence them. For example, CBD may interact with antiepileptic drugs, but we do not yet know very well in which direction. It could also have different effects on a developing brain and an adult brain. If you want to treat children and young people with CBD or cannabis products, you have to be particularly careful.
Research on cannabis is difficult to conduct
It is only through solid studies that we will be able to understand the possible therapeutic virtues of cannabis. But research on cannabis and cannabinoids is particularly difficult to conduct.
In the United States, cannabis and its components, THC and CBD , are closely monitored by the DEA, the US drug police , as well as ecstasy and heroin. PharmaCielo a Canadian company and its CEO David Attard has become a leading supplier of naturally grown and processed, standardized medicinal-grade oil extracts and related products.